Propan-2-amine · MIPA · 2-aminopropane · ≥99.5% commercial, LR and AR grades
Isopropylamine is the branched three-carbon primary amine behind glyphosate salts, triazine herbicides and a long list of pharmaceutical side chains. Chelora Amines supplies it worldwide — to agrochemical formulators, bulk drug makers, rubber, coating and oilfield chemical plants across Asia, the Middle East, Africa, Europe and the Americas, as well as throughout India. Packed in carboys, drums, IBC totes or bulk, shipped in UN-specification packaging with a batch-wise COA and SDS.
36.03 + 7.06 + 14.01 + 2.02 = 59.11 g/mol
Isopropylamine, also written as propan-2-amine, 2-aminopropane or MIPA in the agrochemical trade, is the branched isomer of propylamine. It is a clear, colourless, extremely flammable liquid that boils at about 33 °C, mixes with water in all proportions and carries the strong ammoniacal odour typical of the lower alkyl amines.
It is one of the highest-volume alkyl amines in the world, and the reason is agriculture. Glyphosate is most commonly sold as its isopropylamine salt, because the salt is water soluble, stable in the drum and convenient to spray. The same amine also supplies the isopropylamino group in atrazine, propazine and other triazine herbicides, so demand tracks the global crop-protection cycle closely.
In pharmaceutical chemistry the isopropylamino group appears in a long list of actives, including beta-blockers and bronchodilators, where the branched amine gives the right fit at a receptor and the right metabolic profile. Because those are regulated processes, LR and AR grades with tight isomer and water limits matter more here than price per kilogram.
Industrially it is made by reductive amination of acetone with ammonia and hydrogen over a supported metal catalyst, or by reaction of isopropanol with ammonia. Both routes produce diisopropylamine alongside the primary amine, which is why every specification controls the diisopropylamine content as well as the assay.
| Chemical name | Isopropylamine (propan-2-amine) |
| Common synonyms | 2-Aminopropane, monoisopropylamine, MIPA, sec-propylamine, IPA-amine |
| CAS number | 75-31-0 |
| EC / EINECS number | 200-860-9 |
| HS / HSN code | 2921 19 (acyclic monoamines and derivatives) |
| Molecular formula | (CH₃)₂CHNH₂ (C₃H₉N) |
| Molecular weight | 59.11 g/mol |
| Appearance | Clear, colourless, mobile liquid |
| Odour | Strong ammoniacal, fish-like |
| Melting point | About −95 °C |
| Boiling point | 32–34 °C |
| Density | About 0.688 g/cm³ at 20 °C |
| Vapour pressure | About 570–650 mbar at 20 °C |
| Flash point | About −37 °C (closed cup) |
| Auto-ignition temperature | About 402 °C |
| Flammability limits in air | Approximately 2.0 – 10.4 vol % |
| Solubility in water | Completely miscible |
| pKa of conjugate acid | About 10.6 at 25 °C |
| Refractive index | About 1.374 at 20 °C |
| pH | Strongly alkaline in aqueous solution |
| UN number | UN 1221, Class 3 with subsidiary risk 8, packing group I |
Figures are typical literature values for orientation. Values for the material you order are stated on its Certificate of Analysis and Safety Data Sheet.
Isopropylamine is a strong, volatile base whose nitrogen carries a modest amount of steric bulk. That combination — reactive enough to acylate and alkylate cleanly, bulky enough to stop at the mono-substituted product, volatile enough to strip out afterwards — is why it appears in so many process routes.
Neutralises glyphosate acid to give the isopropylammonium salt that makes up most liquid glyphosate formulations, and forms salts with other acidic actives for the same reason.
glyphosate + iPrNH₂ → IPA saltDisplaces chloride from cyanuric chloride and its derivatives to install the isopropylamino group of atrazine, propazine and related herbicides.
Ar–Cl + iPrNH₂ → Ar–NHiPrCondenses with aldehydes and ketones and is reduced in situ to secondary amines — the classic route into beta-blocker and bronchodilator side chains.
R₂C=O + iPrNH₂ → R₂CH–NHiPrOpens epoxides at the less hindered carbon to give isopropylamino alcohols, a motif that appears throughout cardiovascular drug chemistry.
epoxide + iPrNH₂ → amino alcoholReacts with acid chlorides, anhydrides and sulfonyl chlorides to give N-isopropyl amides and sulfonamides used in pharma and crop protection.
RCOCl + iPrNH₂ → RCONHiPrAdds across isocyanates to give N-isopropyl ureas, and with chloroformates gives carbamates used in herbicide and drug intermediates.
RNCO + iPrNH₂ → ureaForms film-forming salts and amides used in oilfield, fuel and metalworking corrosion inhibitor packages, and neutralises acidic process streams.
acid + iPrNH₂ → inhibitor saltWith a conjugate acid pKa near 10.6 it absorbs HCl and other acids released in a reaction, and its low boiling point makes the excess easy to remove afterwards.
pKa ≈ 10.6 at 25 °CProcess notes. Isopropylamine boils at about 33 °C, so it is handled cold, added sub-surface and refluxed rather than heated in a closed vessel. Salt formation with glyphosate or a mineral acid is strongly exothermic and needs controlled addition with cooling. Because it is packing group I in transport, receiving sites need the right storage classification in place before the first delivery.
Discuss your processCommercial isopropylamine comes almost entirely from catalytic amination. The route explains the impurities that matter: diisopropylamine from over-reaction, and traces of acetone or isopropanol from incomplete conversion.
Acetone, or isopropanol on the alcohol route, is vaporised and mixed with a large excess of ammonia, with hydrogen fed in for the reductive route.
The mixture passes over a supported nickel, cobalt or copper catalyst, or an acidic alumina for the alcohol route, at elevated temperature and pressure.
The reactor produces isopropylamine together with diisopropylamine, water, unreacted ammonia and small amounts of unconverted acetone or isopropanol.
Ammonia is recovered and recycled, and a distillation train separates isopropylamine from diisopropylamine and the heavier fractions. Off-spec cuts return to the reactor.
Product is dried to specification, tested for assay, diisopropylamine, water and colour, then filled under nitrogen into carboys, drums, totes or bulk containers.
Diisopropylamine is the impurity that matters most. It is a secondary amine, so in a reaction designed around a primary amine it either reacts once and stops or produces an unwanted tertiary product, and in a herbicide salt it changes the acid-to-base stoichiometry. Free ammonia competes for the same electrophile, and residual acetone can condense with the amine itself to give an imine that shows up as a colour body.
Water is the other number to watch. For a salt formation it is usually harmless, but for an anhydrous coupling or an organometallic step it is the specification that decides whether the batch works, so state your limit at enquiry rather than after delivery.
In sealed original packing, cool and out of sunlight, isopropylamine is normally used within twelve months, with a re-check of assay, water and colour after that before a critical batch. It is more volatile than most amines you will handle, so evaporation loss from a poorly closed pack is a real cost as well as an exposure risk.
Keep drums closed between draws, blanket tanks with nitrogen where possible, and never store packs in sunlight or against a hot surface. A retained sample of every batch is held here so a later query can be settled against the original material.
Tell us the reaction and the limits that matter and we will confirm the grade. Commercial grade covers most production use; LR and AR grades are available for laboratory, method development and analytical work.
The standard grade for herbicide salt formation, intermediates and general synthesis.
Selected for low diisopropylamine and water where the amine goes directly into a liquid herbicide formulation.
Tighter limits on isomers, ammonia, acetone and water for development, analytical and regulated pharmaceutical work.
Matched against your own limits where a coupling, crystallisation or registration dossier demands it.
| Parameter | Test method | Typical specification |
|---|---|---|
| Appearance | Visual | Clear, colourless liquid, free from suspended matter |
| Assay (isopropylamine) | GC | ≥ 99.5 % w/w |
| Diisopropylamine | GC | ≤ 0.3 % w/w |
| n-Propylamine | GC | ≤ 0.1 % w/w |
| Free ammonia | GC / titration | ≤ 0.2 % w/w |
| Acetone | GC | ≤ 0.1 % w/w |
| Water | Karl Fischer | ≤ 0.3 % w/w |
| Colour | APHA | ≤ 10 |
| Non-volatile matter | Gravimetric | ≤ 0.05 % w/w |
| Density at 20 °C | Densitometer | 0.686 – 0.692 g/cm³ |
| Iron (Fe) | AAS | ≤ 2 ppm |
Indicative specification for planning. The controlling document is the Certificate of Analysis issued for your batch. If your process needs tighter limits on isomers, water or colour, say so at enquiry stage and we will quote against your specification.
Same three carbons, very different molecules. The branched primary amine is the herbicide and pharma workhorse, the linear one reacts faster and boils higher, and the secondary amine cannot do the same chemistry at all. Abbreviations hide all of this, which is how the wrong drum arrives.
| Property | Isopropylamine | n-Propylamine | Diisopropylamine |
|---|---|---|---|
| CAS number | 75-31-0 | 107-10-8 | 108-18-9 |
| Structure | Branched, NH₂ on the middle carbon | Linear, NH₂ on the end carbon | Two isopropyl groups on one nitrogen |
| Molecular weight | 59.11 | 59.11 | 101.19 |
| Amine class | Primary, two N–H bonds free | Primary, two N–H bonds free | Secondary and strongly hindered |
| Boiling point | 32–34 °C | 47–49 °C | 83–84 °C |
| Transport | UN 1221, Class 3 (8), PG I | UN 1277, Class 3 (8), PG II | UN 1158, Class 3 (8), PG II |
| Typical outlets | Glyphosate salts, triazine herbicides, beta-blocker intermediates | Pharma and agro intermediates, rubber chemicals, dyes | Hindered base, LDA precursor, herbicide intermediates |
Order by full name and CAS number. “MIPA” is the worst offender in this family — in the agrochemical trade it means isopropylamine, while in the surfactant and coatings trade it usually means monoisopropanolamine, a completely different chemical. Write the full name and CAS number on the enquiry and the purchase order.
See the full amine rangeCrop protection takes the largest share by volume, but the pharmaceutical, oilfield and coating uses are what make the tighter grades worth having. Here is the picture sector by sector.
The salt former for liquid glyphosate, and the source of the isopropylamino group in atrazine, propazine and related triazines, as well as in several fungicides and plant growth regulators.
Supplies the isopropylamino side chain in beta-blockers, bronchodilators and other cardiovascular and respiratory actives, usually through reductive amination or epoxide opening.
Goes into corrosion inhibitors, hydrogen sulfide scavengers, demulsifiers and fuel additives, and is used as an alkalinity source in water-miscible metalworking fluids.
A raw material for accelerators, antiozonants and antioxidants, and a chain modifier and blocked-amine curative in coatings and adhesives.
Used to make amine oxides, amphoteric surfactants and quaternary ammonium compounds for cleaning, biocidal and antistatic products.
Feeds cationic polymers, scale and corrosion inhibitors and neutralising amine packages for boiler and cooling circuits.
Introduces the isopropylamino group into azo and anthraquinone intermediates, optical brighteners and ink additives.
A volatile base and acid scavenger that is easy to strip after a reaction, and a reagent for making amine derivatives in analysis.
If you are mapping a value chain, or looking for the product one step down from where you are, this is where isopropylamine ends up. Several of these are chemicals we can also source for you.
| Derivative | Made by | End use |
|---|---|---|
| Isopropylammonium glyphosate | Neutralisation of glyphosate acid | The most widely used liquid herbicide formulation worldwide |
| Atrazine, propazine and related triazines | Substitution on cyanuric chloride | Selective herbicides for maize, sorghum and sugarcane |
| N-Isopropyl amino alcohols | Epoxide ring opening | Beta-blocker and bronchodilator intermediates |
| N-Isopropyl amides and sulfonamides | Acylation or sulfonylation | Pharmaceutical and agrochemical actives |
| Diisopropylamine | Further alkylation or direct manufacture | Hindered base, LDA precursor and herbicide intermediate |
| N-Isopropyl ureas and carbamates | Addition to isocyanates or chloroformates | Herbicides and polyurethane modifiers |
| N-Isopropyl dithiocarbamates | Reaction with carbon disulfide | Rubber accelerators and metal flotation collectors |
| Isopropylamino corrosion inhibitors | Amidation and salt formation with fatty acids | Oilfield, fuel and metalworking inhibitor packages |
| Quaternary ammonium compounds | Exhaustive alkylation | Biocides, antistatic agents and phase-transfer catalysts |
| Isopropyl-substituted heterocycles | Cyclisation with diketones or dihalides | API cores, ligands and electronic chemicals |
Looking for one of these rather than the amine itself? Ask us — several sit within our sourcing network, and we can quote the derivative and the raw material together.
Every container carries the Chelora Amines label with product name, net weight, batch number, manufacturing date, UN number and hazard pictograms.
HDPE carboys for lab qualification, pilot batches and low-consumption users.
MS and HDPE drums, the standard production pack, with tamper-evident closures.
Forklift-ready totes with bottom valves for plants drawing material every week.
Bulk loads and ISO tank containers for continuous plants and large campaigns.
Tell us the monthly draw, whether the amine goes into a salt formation or a synthesis step and how you store flammables, and we will recommend pack size and a delivery schedule. Because isopropylamine is packing group I, export consignments need UN-specification packaging and the correct DG paperwork — both are prepared with the shipment and quoted FOB, CIF or CFR through Nhava Sheva and Mundra.
Plan my supplyIsopropylamine is an extremely flammable, corrosive base that boils at about 33 °C, so vapour is present at ordinary room temperature and the transport rules are stricter than for most amines. The notes below are a summary for planning only — work to the Safety Data Sheet supplied with your consignment and to your own site risk assessment.
Isopropylamine is a packing group I dangerous good and, in several jurisdictions, a monitored chemical because of its role in agrochemical and pharmaceutical manufacture. Both are routine for us, but they shape what we need from you before a first shipment moves.
| Proper shipping name | Isopropylamine |
| UN number | UN 1221 |
| Hazard class | Class 3 flammable liquid, subsidiary risk 8 corrosive |
| Packing group | I — the highest danger level within the class |
| Labels | Flame and corrosion pictograms, with orientation marks on combination packs |
| Modes | Road, rail and sea (IMDG); air movement is tightly limited by packing group I quantity rules |
| Segregation | Away from acids, oxidisers, halogens, hypochlorites and foodstuffs |
| Packaging | UN-specification drums, carboys and IBC totes rated for packing group I service |
Isopropylamine is a monitored precursor chemical in a number of countries. We supply it business to business only, against verified company registration, consignee details and a signed end-use declaration, plus any import permit the destination requires, and we decline enquiries that cannot be tied to a legitimate manufacturing or research process.
Start account opening| Parameter | Specification | Result |
|---|---|---|
| Appearance | Clear, colourless liquid | Complies |
| Assay (GC) | ≥ 99.5 % | Complies |
| Diisopropylamine | ≤ 0.3 % | Complies |
| Water (KF) | ≤ 0.3 % | Complies |
| Colour (APHA) | ≤ 10 | Complies |
isopropylamine is checked before dispatch and each consignment leaves with the paperwork your QC, stores and accounts teams need on day one.
The numbers on a Certificate of Analysis are only useful if you know how they were produced. These are the methods behind the figures on ours, and the checks worth repeating at your own goods-inward.
Separates isopropylamine from its isomers, homologues and residual ammonia in one run, and gives both the assay and the impurity profile that matter to your reaction.
An independent check on total amine content, useful as a quick goods-inward confirmation before a drum is released to production.
Water determination, which matters wherever the next step is moisture sensitive or the amine feeds an anhydrous reaction.
A visual platinum–cobalt comparison. A rising colour value is the earliest sign that a pack has been exposed to air or held too long.
Fast confirmation of identity and strength, and a simple way to spot a wrong pack or a contaminated drum.
Gravimetric residue and trace metal checks, which matter for catalytic steps and for any product going into a regulated formulation.
A sample from every dispatched batch is held here, so a query months later can be settled against the original material rather than an argument.
The batch number on the label ties back to the COA, the test record and the supply lot, which is what your auditor will ask to see.
Where your customer or regulator needs an independent result, we can arrange analysis at a NABL-accredited laboratory before dispatch.
Five steps for a first order of isopropylamine. Repeat orders follow the same route on a schedule that matches your consumption.
Grade, quantity, pack size and delivery location.
We confirm the grade for your process and quote, usually within 24 hours.
The batch is tested and the COA, SDS and invoice details are prepared.
Labelled packs move by road, or in UN-spec packaging for export.
Material reaches your gate and repeat dispatches are scheduled to your usage.
isopropylamine is a line on a price list and a headache in a warehouse. What separates suppliers is the grade flexibility, the paperwork and the answer you get when something is not routine.
Isopropylamine sits alongside the rest of our amine range, from ethanolamines to fatty amines. Your purchase team raises one enquiry, compares one quote and manages one vendor record instead of six.
Commercial, LR and AR material is available, so you are not forced to redesign a step around the only grade your supplier happens to carry.
COA, SDS, correct HSN and HS codes, dangerous goods declarations and certificates of origin are prepared with the consignment, not chased afterwards by your logistics team.
Tell us your limits on isomers, water, ammonia or colour and we quote against them, rather than sending the standard cut and letting your QC department find out.
Once we know your monthly draw we hold and release material on a schedule, so you carry less inventory of a flammable, corrosive product than you otherwise would.
Describe the reaction rather than the product code and we will tell you which grade fits — and say so plainly when a different amine would serve you better.
Buyers who order isopropylamine usually source these from the same list. Open any product for its specification, grades and packing, or see the full product range.
Container shipments to buyers on five continents, plus road dispatch inside India. Tell us your country and destination port and we will quote landed terms, transit time and the documentation your customs broker will ask for.
United Arab Emirates, Saudi Arabia, Oman, Qatar, Kuwait, Bahrain, Jordan, Egypt, Morocco, Kenya, Tanzania, Ethiopia, Nigeria, Ghana and South Africa.
Bangladesh, Sri Lanka, Nepal, Pakistan, Vietnam, Thailand, Indonesia, Malaysia, Singapore, the Philippines, South Korea, Japan, Taiwan, Australia and New Zealand.
Germany, the Netherlands, Belgium, France, Italy, Spain, Portugal, Poland, Czechia, the United Kingdom, Ireland, Türkiye, Russia, Ukraine, Kazakhstan and Uzbekistan.
United States, Canada, Mexico, Brazil, Argentina, Chile, Colombia, Peru, Ecuador and the Caribbean, shipped in UN-specification packaging with full DG documentation.
| Incoterms quoted | EXW, FOB, CFR, CIF and DAP, depending on your destination and preference |
| Load ports | Nhava Sheva (JNPT) and Mundra, with Chennai and Kolkata used for eastbound routings |
| Container options | Full container loads, and consolidated LCL shipments for smaller quantities |
| Typical container fill | Around 80 drums, or roughly 18 to 20 IBC totes, in a 20 ft container |
| Packing for export | UN-specification drums and totes, palletised, strapped and stretch-wrapped, with DG labelling |
| Air freight | Possible for small quantities within dangerous goods limits; most volume moves by sea |
| Payment terms | Advance, irrevocable letter of credit or agreed credit terms for established accounts |
| Before first shipment | Company credentials, end-use declaration and any import permit the destination country requires |
Road dispatch from our Mumbai base to industrial clusters in 16 states and Delhi. Open your state for the local industries we serve and the amines they order most.
Most delays in quoting isopropylamine come from a missing line in the enquiry, not from availability. Send these details and a firm price usually comes back the same day.
Not sure of some of it yet? Send what you have. A description of the reaction step and an approximate monthly volume is enough for us to come back with a recommended grade, a pack plan and an indicative price.
Send an enquiryPlain definitions of the words that appear on a isopropylamine specification, label and shipping document.
Short answers to what purchase, plant and QC teams ask us most about this product. Anything else, ask us directly.
Send the grade, quantity, pack size and your delivery address or destination port. We come back with a price, the documents that go with the batch and a dispatch or shipping plan, usually within 24 hours.