X-ray contrast media
Side-chain building block for non-ionic iodinated contrast agents including iohexol and related media.
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3-Aminopropane-1,2-diol · 1-Aminoglycerol · 2,3-Dihydroxypropylamine · Isoserinol
Glycerol with one hydroxyl replaced by an amine — a highly viscous, water-soluble amino diol. Its best-known role is as the side-chain building block of non-ionic iodinated X-ray contrast media such as iohexol. Supplied in drums with COA and SDS.
| CAS number | 616-30-8 |
|---|---|
| EC / EINECS number | 210-475-8 |
| MDL number | MFCD00008140 |
| Molecular formula | C3H9NO2 |
| Molecular weight | 91.11 g/mol |
| Family | Alkanolamine |
| HS code | 2922.19 |
| Appearance | Clear colourless to light yellow highly viscous liquid |
|---|---|
| Boiling point | 264–266 °C at 739 mmHg |
| Flash point | >150 °C |
| Density | 1.175 g/mL at 20 °C |
| Refractive index | 1.490 – 1.494 (n20/D) |
| Solubility in water | Soluble; strongly hygroscopic |
| Storage | Keep sealed, below 30 °C |
Industrially it is made by reacting 3-chloro-1,2-propanediol with ammonia under alkaline conditions. The three polar groups give it high viscosity and strong water affinity, which is exactly what contrast-media chemistry needs: solubility and tolerability built into the side chain.
Because it absorbs moisture quickly, drums should be resealed immediately and water content checked before use in any reaction where stoichiometry or acylation yield matters.
Side-chain building block for non-ionic iodinated contrast agents including iohexol and related media.
Chiral glycerol derivative used across fine-chemical and API synthesis.
Starting material for functional polymers, resins and coating modifiers.
Hydrophilic amine head group for mild surfactants and chelating agents.
| PARAMETER | TYPICAL VALUE | METHOD |
|---|---|---|
| Appearance | Clear colourless to light yellow viscous liquid | Visual |
| Assay | min. 98.0 % | Titration with HClO4 |
| Water content | max. 0.5 % | Karl Fischer |
| Refractive index | 1.4900 – 1.4940 at 20 °C | n20/D |
| Identity | Conforms to structure | IR |
| Colour | max. 100 APHA | Pt–Co |
Typical values only — batch figures are stated on the certificate of analysis. Custom specifications on request.
225 kg HDPE drums, 25 kg jerricans and 1 kg laboratory packs. Nitrogen-blanketed filling on request.
3-Amino-1,2-propanediol is registered under CAS number 616-30-8, EC number 210-475-8, with the molecular formula C3H9NO2 and a molecular weight of 91.11 g/mol.
Its main use is in the preparation of non-ionic X-ray contrast media such as iohexol. It is also used as a chiral glycerol derivative in pharmaceutical synthesis and as a starting material for specialty polymers, surfactants and chelating agents.
It is a clear, highly viscous liquid at room temperature with a density of about 1.175 g/mL, and it boils around 264 to 266 °C at 739 mmHg.
In tightly closed containers below 30 °C, protected from moisture. The material is strongly hygroscopic, so water pick-up is the main cause of off-spec assay.
Chelora Amines supplies 3-amino-1,2-propanediol in 225 kg HDPE drums, 25 kg jerricans and 1 kg laboratory packs, with a certificate of analysis and safety data sheet on every despatch.
| CAS NUMBER | CHEMICAL NAME | FAMILY | |
|---|---|---|---|
| 61-82-5 | 3-Amino-1,2,4-triazole Amitrole, ATA |
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| 260-94-6 | Acridine Dibenzo[b,e]pyridine |
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| 107-11-9 | Allylamine 3-Aminopropene |
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See all 36 chemicals under A · 333 chemicals in the full glossary
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